diff --git a/src/internal/syscall/unix/nonblocking.go b/src/internal/syscall/unix/nonblocking.go
index a0becd1e01e04d3db393f8562f5e17114c684d06..6c6f0674d66702f58a70021602c5cb9f265309eb 100644
--- a/src/internal/syscall/unix/nonblocking.go
+++ b/src/internal/syscall/unix/nonblocking.go
@@ -19,3 +19,7 @@ func IsNonblock(fd int) (nonblocking bool, err error) {
 	}
 	return flag&syscall.O_NONBLOCK != 0, nil
 }
+
+func HasNonblockFlag(flag int) bool {
+	return flag&syscall.O_NONBLOCK != 0
+}
diff --git a/src/internal/syscall/unix/nonblocking_js.go b/src/internal/syscall/unix/nonblocking_js.go
index 8ed40f3f9104adcd09159a2e73e949d763a5259c..cfe78c58d8de2c2bac2f173e98a6908aac051b95 100644
--- a/src/internal/syscall/unix/nonblocking_js.go
+++ b/src/internal/syscall/unix/nonblocking_js.go
@@ -9,3 +9,7 @@ package unix
 func IsNonblock(fd int) (nonblocking bool, err error) {
 	return false, nil
 }
+
+func HasNonblockFlag(flag int) bool {
+	return false
+}
diff --git a/src/internal/syscall/unix/nonblocking_libc.go b/src/internal/syscall/unix/nonblocking_libc.go
index bff668496236e680aa21772299db9369abc402a5..1310dbf8ce5478f82ace66958a541d50249d555d 100644
--- a/src/internal/syscall/unix/nonblocking_libc.go
+++ b/src/internal/syscall/unix/nonblocking_libc.go
@@ -19,6 +19,10 @@ func IsNonblock(fd int) (nonblocking bool, err error) {
 	return flag&syscall.O_NONBLOCK != 0, nil
 }
 
+func HasNonblockFlag(flag int) bool {
+	return flag&syscall.O_NONBLOCK != 0
+}
+
 // Implemented in the syscall package.
 //
 //go:linkname fcntl syscall.fcntl
diff --git a/src/internal/syscall/unix/nonblocking_wasip1.go b/src/internal/syscall/unix/nonblocking_wasip1.go
index 208db28c3efdb119dae82774ed206878445eb817..5b2b53bf5c3c6860e413229c43ad52e86574f5d4 100644
--- a/src/internal/syscall/unix/nonblocking_wasip1.go
+++ b/src/internal/syscall/unix/nonblocking_wasip1.go
@@ -19,6 +19,10 @@ func IsNonblock(fd int) (nonblocking bool, err error) {
 	return flags&syscall.FDFLAG_NONBLOCK != 0, nil
 }
 
+func HasNonblockFlag(flag int) bool {
+	return flag&syscall.FDFLAG_NONBLOCK != 0
+}
+
 // This helper is implemented in the syscall package. It means we don't have
 // to redefine the fd_fdstat_get host import or the fdstat struct it
 // populates.
diff --git a/src/os/fifo_test.go b/src/os/fifo_test.go
index 867c294f5ecbbacb7b30517300a242ab58217724..df4b2ee757c6a58ef6f146b0ae37ee9bacf944a1 100644
--- a/src/os/fifo_test.go
+++ b/src/os/fifo_test.go
@@ -8,6 +8,7 @@ package os_test
 
 import (
 	"errors"
+	"internal/syscall/unix"
 	"internal/testenv"
 	"io/fs"
 	"os"
@@ -155,3 +156,52 @@ func TestNonPollable(t *testing.T) {
 		}
 	}
 }
+
+// Issue 60211.
+func TestOpenFileNonBlocking(t *testing.T) {
+	exe, err := os.Executable()
+	if err != nil {
+		t.Skipf("can't find executable: %v", err)
+	}
+	f, err := os.OpenFile(exe, os.O_RDONLY|syscall.O_NONBLOCK, 0666)
+	if err != nil {
+		t.Fatal(err)
+	}
+	defer f.Close()
+	nonblock, err := unix.IsNonblock(int(f.Fd()))
+	if err != nil {
+		t.Fatal(err)
+	}
+	if !nonblock {
+		t.Errorf("file opened with O_NONBLOCK but in blocking mode")
+	}
+}
+
+func TestNewFileNonBlocking(t *testing.T) {
+	var p [2]int
+	if err := syscall.Pipe(p[:]); err != nil {
+		t.Fatal(err)
+	}
+	if err := syscall.SetNonblock(p[0], true); err != nil {
+		t.Fatal(err)
+	}
+	f := os.NewFile(uintptr(p[0]), "pipe")
+	nonblock, err := unix.IsNonblock(p[0])
+	if err != nil {
+		t.Fatal(err)
+	}
+	if !nonblock {
+		t.Error("pipe blocking after NewFile")
+	}
+	fd := f.Fd()
+	if fd != uintptr(p[0]) {
+		t.Errorf("Fd returned %d, want %d", fd, p[0])
+	}
+	nonblock, err = unix.IsNonblock(p[0])
+	if err != nil {
+		t.Fatal(err)
+	}
+	if !nonblock {
+		t.Error("pipe blocking after Fd")
+	}
+}
diff --git a/src/os/file_unix.go b/src/os/file_unix.go
index f7f942f5f528e45ea98a75c423ee2014529a3bf3..3d3a8b2056b793bd7ddf3e1d9cbf3eb0ca584693 100644
--- a/src/os/file_unix.go
+++ b/src/os/file_unix.go
@@ -116,12 +116,12 @@ const (
 	// kindNewFile means that the descriptor was passed to us via NewFile.
 	kindNewFile newFileKind = iota
 	// kindOpenFile means that the descriptor was opened using
-	// Open, Create, or OpenFile.
+	// Open, Create, or OpenFile (without O_NONBLOCK).
 	kindOpenFile
 	// kindPipe means that the descriptor was opened using Pipe.
 	kindPipe
-	// kindNonBlock means that the descriptor was passed to us via NewFile,
-	// and the descriptor is already in non-blocking mode.
+	// kindNonBlock means that the descriptor is already in
+	// non-blocking mode.
 	kindNonBlock
 	// kindNoPoll means that we should not put the descriptor into
 	// non-blocking mode, because we know it is not a pipe or FIFO.
@@ -184,7 +184,9 @@ func newFile(fd uintptr, name string, kind newFileKind) *File {
 	clearNonBlock := false
 	if pollable {
 		if kind == kindNonBlock {
-			f.nonblock = true
+			// The descriptor is already in non-blocking mode.
+			// We only set f.nonblock if we put the file into
+			// non-blocking mode.
 		} else if err := syscall.SetNonblock(fdi, true); err == nil {
 			f.nonblock = true
 			clearNonBlock = true
@@ -263,7 +265,12 @@ func openFileNolog(name string, flag int, perm FileMode) (*File, error) {
 		syscall.CloseOnExec(r)
 	}
 
-	f := newFile(uintptr(r), name, kindOpenFile)
+	kind := kindOpenFile
+	if unix.HasNonblockFlag(flag) {
+		kind = kindNonBlock
+	}
+
+	f := newFile(uintptr(r), name, kind)
 	f.pfd.SysFile = s
 	return f, nil
 }